Fbxo7/PARK15 has well-defined roles, acting as part of a Skp1-Cul1-F box protein (SCF)-
type E3 ubiquitin ligase and also having SCF-independent activities. Mutations within FBXO7 have
been found to cause an early-onset Parkinson’s disease, and these are found within or near to its functional
domains, including its F-box domain (FBD), its proline rich region (PRR), and its ubiquitinlike
domain (Ubl). We highlight recent advances in our understanding of Fbxo7 function in Parkinson’s
disease, with respect to these mutations and where they occur in the Fbxo7 protein. We hypothesize
that many of Fbxo7 functions contribute to its role in PD pathogenesis.
Keywords: Fbxo7/PARK15, F-box protein, SCF-ligase, ubiquitin, E3 ligase, Parkinson’s disease, mitophagy.
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