Title:Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy
VOLUME: 17 ISSUE: 8
Author(s):Mark Walsh, Stephanie Fritz, Daniel Hake, Michael Son, Sarah Greve, Manar Jbara, Swetha Chitta, Braxton Fritz, Adam Miller, Mary K Bader, Jonathon McCollester, Sophia Binz, Alyson Liew-Spilger, Scott Thomas, Anton Crepinsek, Faisal Shariff, Victoria Ploplis and Francis J. Castellino
Affiliation:Memorial Hospital of South Bend, South Bend, Indiana 46601, USA.
Keywords:Thromboelastography, point-of-care, acquired coagulopathy, blood component therapy, systemic hemostatic
agents, trauma-induced coagulopathy, hemostatic resuscitation, tranexamic acid, targeted pharmacologic therapy.
Abstract:Trauma-induced coagulopathy (TIC) is a recently described condition which traditionally
has been diagnosed by the common coagulation tests (CCTs) such as prothrombin time/international
normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), platelet count, and fibrinogen
levels. The varying sensitivity and specificity of these CCTs have led trauma coagulation researchers
and clinicians to use Viscoelastic Tests (VET) such as Thromboelastography (TEG) to provide Targeted Thromboelastographic
Hemostatic and Adjunctive Therapy (TTHAT) in a goal directed fashion to those trauma patients in need of hemostatic
resuscitation. This review describes the utility of VETs, in particular, TEG, to provide TTHAT in trauma and acquired
non-trauma-induced coagulopathy.
