Globally, thrombosis-associated disorders are one of the main contributors to fatalities.
Besides genetic influences, there are some acquired and environmental risk factors dominating
thrombotic diseases. Although standard regimens have been used for a long time, many side
effects still occur which can be life threatening. Therefore, natural products are good alternatives.
Although the quest for antithrombotic natural products came to light only since the end of last
century, in the last two decades, a considerable number of natural products showing antithrombotic
activities (antiplatelet, anticoagulant and fibrinolytic) with no or minimal side effects have
been reported. In this review, several natural products used as antithrombotic agents including
medicinal plants, vegetables, fruits, spices and edible mushrooms which have been discovered in the last 15 years and their target sites
(thrombogenic components, factors and thrombotic pathways) are described. In addition, the side effects, limitations and interactions of
standard regimens with natural products are also discussed. The active compounds could serve as potential sources for future research on
antithrombotic drug development. As a future direction, more advanced researches (in quest of the target cofactor or component involved
in antithrombotic pathways) are warranted for the development of potential natural antithrombotic medications (alone or combined with
standard regimens) to ensure maximum safety and efficacy.