Background: When concentrations of both reactive oxygen species and reactive nitrogen species exceed
the antioxidative capability of an organism, the cells undergo oxidative impairment. Impairments in membrane integrity
and lipid and protein oxidation, protein mutilation, DNA damage, and neuronal dysfunction are some of the
fundamental consequences of oxidative stress. Methods: The purpose of this work was to review the associations
between oxidative stress and psychological disorders. The search terms were the following: “oxidative stress and
affective disorders,” “free radicals and neurodegenerative disorders,” “oxidative stress and psychological disorders,”
“oxidative stress, free radicals, and psychiatric disorders,” and “association of oxidative stress.” These search terms were used in
conjunction with each of the diagnostic categories of the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental
Disorders and World Health Organization’s International Statistical Classification of Diseases and Related Health Problems.
Results: Genetic, pharmacological, biochemical, and preclinical therapeutic studies, case reports, and clinical trials were selected to explore
the molecular aspects of psychological disorders that are associated with oxidative stress. We identified a broad spectrum of 83 degenerative
syndromes and psychiatric disorders that were associated with oxidative stress. Conclusion: The multi-dimensional information
identified herein supports the role of oxidative stress in various psychiatric disorders. We discuss the results from the perspective of
developing novel therapeutic interventions.