Nature and Nurture in the Early-Life Origins of Metabolic Syndrome

Author(s): Antonio Gonzalez-Bulnes, Susana Astiz, Cristina Ovilo, Consolacion Garcia-Contreras, Marta Vazquez-Gomez

Journal Name: Current Pharmaceutical Biotechnology

Volume 17 , Issue 7 , 2016

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The combination of genetic background together with food excess and lack of exercise has become the cornerstone of metabolic disorders associated to lifestyle. The scenario is furthermore reinforced by their interaction with other environmental factors (stress, sleeping patterns, education, culture, rural versus urban locations, and xenobiotics, among others) inducing epigenetic changes in the exposed individuals. The immediate consequence is the development of further alterations like obesity and metabolic syndrome, and other adverse health conditions (type-2 diabetes, cardiovascular diseases, cancer, reproductive, immune and neurological disorders). Thus, having in mind the impact of the metabolic syndrome on the worldwide public health, the present review affords the relative roles and the interrelationships of nature (genetic predisposition to metabolic syndrome) and nurture (lifestyle and environmental effects causing epigenetic changes), on the establishment of the metabolic disorders in women; disorders that may evolve to metabolic syndrome prior or during pregnancy and may be transmitted to their descendants.

Keywords: Developmental-programming, endocrine-disrupting-chemicals, epigenetics, lifestyle, metabolic-syndrome, nutrition, obesogenics, transgenerational-programming.

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Article Details

Year: 2016
Published on: 29 February, 2016
Page: [573 - 586]
Pages: 14
DOI: 10.2174/1389201017666160301103835
Price: $65

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