Anti-Inflammatory Activities of Some Bee Products by Inhibition of Bovine Testes Hyaluronidase

Author(s): Sevgi Kolayli, Hilal Ebru Cakir, Huseyin Sahin, Zehra Can, Oktay Yildiz

Journal Name: Current Enzyme Inhibition

Volume 12 , Issue 2 , 2016

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Graphical Abstract:


Background: Apitherapeutic products contain many valuable bioactive compounds which are responsible for biologically active features such as anti-oxidant, anti-viral, anti-microbial and anti-inflammatory properties.

Objective: This study investigated in vitro anti-inflammatory potentials in terms of hyaluronidase inhibition of three different bee products, propolis, pollens and royal jellies.

Methods: Water soluble extracts of the samples were prepared, and inhibitions of bovine serum hyaluronidase were used. Inhibitions were expressed as percentages of inhibition (IC50;g/mL or mg/mL) causing 50% inhibition of the enzyme.

Results: All the bee products exhibited anti-hyaluronidase activities in the order propolis, pollen, and finally royal jelly. Inhibition was also correlated with the samples’ total phenolic contents.

Conclusion: The study results confirm that water-soluble propolis is the best inhibitory agent among the bee products, and that these may be used as anti-inflammatory agents. However, further in vivo studies are now needed to clarify their pharmaceutical potentials as medicines.

Keywords: Anti-inflammatory, hyaluronidase, propolis, pollen, royal jelly, phenolics.

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Article Details

Year: 2016
Page: [183 - 187]
Pages: 5
DOI: 10.2174/1573408012666160229224038
Price: $65

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