Background: Apitherapeutic products contain many valuable bioactive compounds which are responsible for
biologically active features such as anti-oxidant, anti-viral, anti-microbial and anti-inflammatory properties.
Objective: This study investigated in vitro anti-inflammatory potentials in terms of hyaluronidase inhibition of three different
bee products, propolis, pollens and royal jellies.
Methods: Water soluble extracts of the samples were prepared, and inhibitions of bovine serum hyaluronidase were used.
Inhibitions were expressed as percentages of inhibition (IC50;g/mL or mg/mL) causing 50% inhibition of the enzyme.
Results: All the bee products exhibited anti-hyaluronidase activities in the order propolis, pollen, and finally royal jelly.
Inhibition was also correlated with the samples’ total phenolic contents.
Conclusion: The study results confirm that water-soluble propolis is the best inhibitory agent among the bee products,
and that these may be used as anti-inflammatory agents. However, further in vivo studies are now needed to clarify their
pharmaceutical potentials as medicines.