Assessment of toxicity is an important component of the drug discovery process. Cellbased
assays are a popular choice for assessing cytotoxicity. However, these assays are complex because
of the wide variety of formats and methods that are available, lack of standardization, confusing
terminology and the inherent variability of biological systems and measurement. This review is
intended as a guide on how to take these factors into account when planning, conducting and/or interpreting
cell based toxicity assays.
Keywords: Cytotoxicity, cytotoxicity screening, viability assays, apoptosis, cell-based assays, toxicity.
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