Drug Discovery and Development of Antimalarial Agents: Recent Advances

Author(s): Sreekanth Thota, Rajeshwar Yerra

Journal Name: Current Protein & Peptide Science

Volume 17 , Issue 3 , 2016


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Abstract:

Malaria, a deadly infectious parasitic disease, is a major issue of public health in the world today and already produces serious economic constraints in the endemic countries. Most of the malarial infections and deaths are due to Plasmodium falciparum and Plasmodium vivax species. The recent emergence of resistance necessitates the search for new antimalarial drugs, which overcome the resistance and act through new mechanisms. Although much effort has been directed towards the discovery of novel antimalarial drugs. 4-anilino quinolone triazines as potent antimalarial agents, their in silico modelling and bioevaluation as Plasmodium falciparum transketolase and β-hematin inhibitors has been reported. This review is primarily focused on the drug discovery of the recent advances in the development of antimalarial agents and their mechanism of action.

Keywords: Antimalarial drugs, Malaria, Mechanism of action, Plasmodium falciparum, Plasmodium vivax.

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Article Details

VOLUME: 17
ISSUE: 3
Year: 2016
Published on: 10 March, 2016
Page: [275 - 279]
Pages: 5
DOI: 10.2174/1389203717999160226180543
Price: $65

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