Nuclear phosphoinositide-phospholipase C (PI-PLC) beta1 plays a crucial role in the molecular steps
that regulate cell proliferation and differentiation in several experimental models, such as myoblasts and hematopoietic
cells, via interaction with other important molecular players. Indeed, PI-PLCbeta1 and its related molecules
are definitely involved in hematopoiesis, and particularly in drug-induced myeloid or erythroid differentiation.
Here, we review the role of nuclear PI-PLCbeta1 signalling in normal hematopoiesis, in pathogenesis and in
drug-related induction of hematopoietic differentiation, with particular reference to the current therapy of
Myelodysplastic Syndromes (MDS).
Keywords: PI-PLCbeta1, Nucleus, Cell Cycle, Differentiation, Hematopoiesis, MDS.
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