Natural products bearing a triazaspirocyclic motif have received significant attention in recent
years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon
forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications
in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles
in Nature, their biological activity, and applications. Methods for the synthesis of triazaspirocycles as
well as the reactivity of triazaspirocyclic scaffolds will be reviewed.
Keywords: 1, 3 Dipolar cycloaddition, cycloreversion, N-heterocyclic carbene, nitrogen heterocycles,
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