Triazaspirocycles: Occurrence, Synthesis, and Applications

Author(s): Claire M. Gober, Patrick J. Carroll, Madeleine M. Joullié

Journal Name: Mini-Reviews in Organic Chemistry

Volume 13 , Issue 2 , 2016

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Graphical Abstract:


Natural products bearing a triazaspirocyclic motif have received significant attention in recent years. These compounds, which feature three nitrogen atoms attached to one quaternary carbon forming a spirocyclic scaffold, exhibit a wide range of biological activity and have promising applications in materials as well as in drug discovery. In this review article, we will discuss triazaspirocycles in Nature, their biological activity, and applications. Methods for the synthesis of triazaspirocycles as well as the reactivity of triazaspirocyclic scaffolds will be reviewed.

Keywords: 1, 3 Dipolar cycloaddition, cycloreversion, N-heterocyclic carbene, nitrogen heterocycles, spirocycles, triaza.

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Article Details

Year: 2016
Page: [126 - 142]
Pages: 17
DOI: 10.2174/1570193X13666160225001001
Price: $65

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