Telomerase Inhibitors: Potential Anticancer Agents

Author(s): Rakesh R. Somani, Mayuri H. Patel

Journal Name: Mini-Reviews in Organic Chemistry

Volume 13 , Issue 1 , 2016

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Abstract:

Telomerase activation is a hallmark of cancer. Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to synthesize the repetitive G-rich DNA found at the 3 ends of chromosomes (Telomere). Most cancer cells upregulates telomerase to attain cellular immortalization and cell regulation, whereas, telomerase in normal human somatic cells have a limited proliferative capacity both In-vitro and In-vivo and undergo senescence. Due to the differential expression pattern of telomerase between normal and tumor cells, telomerase has received significant attention as a universal cancer target. Additionally, since telomerase is expressed in stem cells during all stages of life, it has been linked to the process of aging and age-related diseases. Despite the great interest in telomerase, current understanding of telomerase and its regulation remains limited.

Keywords: Aging, cancer, G-quadruplex, senescence, telomerase inhibitor, telomerase.

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Article Details

VOLUME: 13
ISSUE: 1
Year: 2016
Page: [49 - 61]
Pages: 13
DOI: 10.2174/1570193X13666160225000624

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