Telomerase activation is a hallmark of cancer. Telomerase is a specialized ribonucleoprotein
complex that uses its RNA subunit to synthesize the repetitive G-rich DNA found at the 3 ends of
chromosomes (Telomere). Most cancer cells upregulates telomerase to attain cellular immortalization
and cell regulation, whereas, telomerase in normal human somatic cells have a limited proliferative
capacity both In-vitro and In-vivo and undergo senescence. Due to the differential expression pattern
of telomerase between normal and tumor cells, telomerase has received significant attention as a universal
cancer target. Additionally, since telomerase is expressed in stem cells during all stages of life,
it has been linked to the process of aging and age-related diseases. Despite the great interest in telomerase,
current understanding of telomerase and its regulation remains limited.
Keywords: Aging, cancer, G-quadruplex, senescence, telomerase inhibitor, telomerase.
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