Abstract
Telomerase activation is a hallmark of cancer. Telomerase is a specialized ribonucleoprotein complex that uses its RNA subunit to synthesize the repetitive G-rich DNA found at the 3 ends of chromosomes (Telomere). Most cancer cells upregulates telomerase to attain cellular immortalization and cell regulation, whereas, telomerase in normal human somatic cells have a limited proliferative capacity both In-vitro and In-vivo and undergo senescence. Due to the differential expression pattern of telomerase between normal and tumor cells, telomerase has received significant attention as a universal cancer target. Additionally, since telomerase is expressed in stem cells during all stages of life, it has been linked to the process of aging and age-related diseases. Despite the great interest in telomerase, current understanding of telomerase and its regulation remains limited.
Keywords: Aging, cancer, G-quadruplex, senescence, telomerase inhibitor, telomerase.
Graphical Abstract
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
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