Restless Legs Syndrome/Willis-Ekbom Disease and Periodic Limb Movements: A Comprehensive Review of Epidemiology, Pathophysiology, Diagnosis and Treatment Considerations

Author(s): Dyveke P. Pratt

Journal Name: Current Rheumatology Reviews

Volume 12 , Issue 2 , 2016

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Graphical Abstract:


Restless legs syndrome (RLS) or Willis-Ekbom Disease is a common, but frequently under- recognized and misdiagnosed condition seen in many subspecialty practices including neurology, sleep medicine, primary care and rheumatology. Periodic limb movements are a frequent co-morbid diagnosis in RLS. Despite prior beliefs that the condition was “benign”, it has been demonstrated to have a considerable impact on sufferers quality of life, physically and psychologically, as well as socially. This chapter is meant as a comprehensive review of RLS encompassing epidemiology, pathophysiology, diagnosis, and treatment considerations.

Keywords: Restless legs syndrome, RLS, willis-ekbom disease, WED, periodic limb movements, PLMs.

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Article Details

Year: 2016
Published on: 23 February, 2016
Page: [91 - 112]
Pages: 22
DOI: 10.2174/1573403X12666160223120340
Price: $65

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PDF: 52