Nanoparticles (NPs), the submicron-sized colloidal particles, have recently generated enormous
interest among biomedical scientists, particularly in cancer therapy. A number of models are being
used for exploring NPs safety and efficacy. Recently, cancer cell lines have explored as prominent
experimental models for evaluating pharmacokinetic parameters, cell viability, cytotoxicity and drug
efficacy in tumor cells. This review aims at thorough compilation of various cancer cell lines and in
vivo models for evaluation of efficacy of NPs on one platform. This will provide a basis to explore and
improvise pre-clinical models as a prelude to successful cancer research.
Keywords: Cancer, cell lines studies, chemotherapy, cytotoxicity, ex vivo studies, nanoparticles.
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