Title:Significance of Various Experimental Models and Assay Techniques in Cancer Diagnosis
VOLUME: 17 ISSUE: 18
Author(s):Raksha Ghanghoria, Prashant Kesharwani* and Narendra K. Jain*
Affiliation:Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, MP, International Medical University, School of Pharmacy, Department of Pharmaceutical Technology, Kuala Lumpur 57000, Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470003, MP
Keywords:Animal models, cancer, chemotherapy, cell lines studies, in vitro models, in vitro studies.
Abstract:The experimental models are of vital significance to provide information regarding biological
as well as genetic factors that control the phenotypic characteristics of the disease and serve as the
foundation for the development of rational intervention stratagem. This review highlights the importance
of experimental models in the field of cancer management. The process of pathogenesis in cancer progression,
invasion and metastasis can be successfully explained by employing clinically relevant laboratory
models of the disease. Cancer cell lines have been used extensively to monitor the process of cancer
pathogenesis process by controlling growth regulation and chemo-sensitivity for the evaluation of novel
therapeutics in both in vitro and xenograft models. The experimental models have been used for the
elaboration of diagnostic or therapeutic protocols, and thus employed in preclinical studies of bioactive
agents relevant for cancer prevention. The outcome of this review should provide useful information in
understanding and selection of various models in accordance with the stage of cancer.
