Increasing evidence suggests that stem cells, a small population of cells with unique selfrenewable
and tumour regenerative capacity, are aiding tumour re-growth and multidrug resistance.
Conventional therapies are highly ineffective at eliminating these cells leading to relapse of disease
and formation of chemoresistance tumours. Cancer and stem cells targeted therapies that utilizes nanotherapeutics
to delivery anti-cancer drugs to specific sites are continuously investigated. This review
focuses on recent research using nanomedicine and targeting entities to eliminate cancer cells and cancer
stem cells. Current nanotherapeutics in clinical trials along with more recent publications on targeted
therapies are addressed.
Keywords: Aptamers, cancer, chemotherapeutics, stem cells, nanotherapeutics, nanomedicine.
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