Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles

Title:Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles

Volume: 20 Issue: 15

Author(s): Mohammad A. Bodaghifard, Zahra Faraki and Ali R. Karimi

Affiliation:

Keywords: Nanoparticles, magnetite, heterogeneous catalysis, sulfamic acid, imidazo[1, 2-a]pyrimidine, multicomponent reaction.

Abstract: Alkyl disulfamic acid-functionalized silica-coated magnetic nanoparticles (ADSA-MNPs) have been synthesized as a hybrid organic- inorganic acidic nanoparticles and its catalytic activity has been evaluated in the synthesis of mono-, bis- and tris 1,2-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine via a one-pot three, pseudo-five or pseudo-seven component condensation reaction of aromatic aldehydes, malononitrile and 2-aminobezimidazole under solvent-free heating. The heterogeneous catalyst was facilely separated from the reaction mixture by utilizing external magnetic field and reused for several times without considerable decrease of catalytic performance.

Cite this article as:

A. Bodaghifard Mohammad, Faraki Zahra and R. Karimi Ali, Mild Synthesis of mono-, bis- and tris 1,2-Dihydrobenzo[4,5]imidazo[1,2- a]pyrimidine Derivatives Using Alkyl Disulfamic Acid Functionalized Magnetic Nanoparticles, Current Organic Chemistry 2016; 20 (15) . https://dx.doi.org/10.2174/1385272820666160218233729