The development of induced pluripotent stem cell (iPSC) technology has inspired a series of
methods to manipulate cell fate and has provided novel insight into the profound molecular events underlying
the development of diseases. Reprogramming somatic cells into iPSCs has been intensively
investigated. However, few studies have investigated the reprogramming of malignant cells and its potential
application. Herein, we review the recent progress of iPSCs derived from malignant cells, and highlight tumor
iPSCs applications on cancer research which mainly focus on mesenchymal-epithelial transition, genetic and epigenetic
change, diseases model construction, drug screening and tumor pathway study.