Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including
coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially
understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial
dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression
of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in
general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.
Keywords: Antioxidants, Mitochondria, Muscle, Oxidative stress, Type 2 diabetes.
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