Title:Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action
VOLUME: 23 ISSUE: 9
Author(s):Solomon Habtemariam
Affiliation:Pharmacognosy Research Laboratories & Herbal Analysis Services, Chatham- Maritime, Kent ME4 4TB, UK.
Keywords:Rutin, quercetin-3-O-rutinoside, Alzheimer’s disease, neurodegeneration, amyloid-beta.
Abstract:Rutin (quercetin-3-O-rutinoside) is a multifunctional natural flavonoid glycoside
with profound effects on the various cellular functions under pathological conditions.
Due to the ability of rutin and/or its metabolites to cross the blood brain barrier, it has also
been shown to modify the cognitive and various behavioral symptoms of neurodegenerative
diseases. In this review, its therapeutic potential for Alzheimer’s disease (AD) is
evaluated through appraisal of current literatures relevant to the various cellular and
molecular targets of the disease. Among the most relevant mechanisms involved are effect on amyloid
beta (Aβ) processing, aggregation and action; alteration of the oxidant-antioxidant balance associated
with neuronal cell loss; removing the inflammatory component of neurodegeneration, etc. The effect of rutin
resulting from its physicochemical features related to effects like metal chelation and bioavailability are also
discussed.
