Diels-Alder Cycloaddition in Medicinal Chemistry

Author(s): Laure C. Bouchez, Marion Rusch, Marie-Helene Larraufie

Journal Name: Current Organic Chemistry

Volume 20 , Issue 22 , 2016

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Graphical Abstract:


Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding of steric and electronic effects have allowed the development of many different versions including intramolecular [4+2] cycloadditions, hetero-Diels-Alder reactions, and catalytic asymmetric variants, among others. In this chapter, we will give an overview on the application of Diels-Alder reactions in Medicinal Chemistry.

Keywords: Diels-Alder reaction, [4+2] cycloaddition, medicinal chemistry, drug-like molecules, Diels-Alderase.

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Article Details

Year: 2016
Published on: 16 August, 2016
Page: [2358 - 2378]
Pages: 21
DOI: 10.2174/1385272820666160216000558
Price: $58

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