The Diels-Alder reactions can be classified as click reactions because of their
simplicity and high yields. The Diels-Alder click reactions have been used for the preparation
of complex macromolecules, such as hydrogels and polymers and also for labeling of
various biological targets. This review summarizes the recent application of Diels-Alder
click reactions in hydrogel synthesis, polymer and material science and also medicinal application
of Diels-Alder click reaction.
Keywords: Click reaction, Diels-Alder, hydrogels, inverse electron demand Diels-Alder reactions, polymers.
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