Research over the years has gradually and sequentially highlighted contributory role of hypothalamic-
based kisspeptin-signaling axis as a major positive modulator of the neuroendocrinological
reproductive axis in mammals. However, a series of landmark studies provided convincing evidence
of role of this signaling in regulation of cancer development and progression. It is becoming progressively
more understandable that loss or reduction of KISS1 expression in different human cancers correlates
inversely with progression of tumor, metastasizing potential and survival. In this review we have attempted to provide
an overview highlight of the most recent updates addressing metastasis- suppressing role of KISS1. We also summarize
interplay of microRNA and KISS1 in cancer. The miRNA regulation of different genes is a rapidly expanding area of
research however, the community lacks a deep understanding of miRNA regulation of KISS1. Recently, emerging laboratory
findings have shown that KISS1 is transcriptionally controlled by TCF21 that is in turn regulated by miR-21. Therefore,
there is an urgent need for further study of how miRNA directly or indirectly influences KISS1 at the posttranscriptional
level. There is also a lack of evidence regarding natural agents that mediate upregulation or downregulation
of KISS1. Increasing the knowledge of the KISS1/KISS1R signaling axis will be helpful in achieving personalized medicine.
Keywords: Apoptosis, Cancer, Kisspeptin, miRNA, Signaling, Xenograft.
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