The Unexpected Advantages of Using D-Amino Acids for Peptide Self- Assembly into Nanostructured Hydrogels for Medicine

Author(s): Michele Melchionna, Katie E. Styan, Silvia Marchesan

Journal Name: Current Topics in Medicinal Chemistry

Volume 16 , Issue 18 , 2016

Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Self-assembled peptide hydrogels have brought innovation to the medicinal field, not only as responsive biomaterials but also as nanostructured therapeutic agents or as smart drug delivery systems. D-amino acids are typically introduced to increase the peptide enzymatic stability. However, there are several reports of unexpected effects on peptide conformation, self-assembly behavior, cytotoxicity and even therapeutic activity. This mini-review discusses all the surprising twists of heterochiral self-assembled peptide hydrogels, and delineates emerging key findings to exploit all the benefits of D-amino acids in this novel medicinal area.

Keywords: Chirality, D-Amino acids, Enantiomers, Heterochiral, Hydrogels, Nanomaterials, Peptides, Self-assembly.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2016
Published on: 12 February, 2016
Page: [2009 - 2018]
Pages: 10
DOI: 10.2174/1568026616999160212120302

Article Metrics

PDF: 106