Angiogenesis is indispensible for tumor growth and metastasis.
Antiangiogenic therapy is now a validated major strategy in cancer clinic; several
small molecule angiogenic inhibitors have been successfully translated into clinic for
multiple cancer indications. In the past decade, many natural products with potent
antiangiogenic activity were explored and the underlying molecular mechanisms
were revealed. One important mechanism is the inhibition of one or several steps in
VEGF/VFGFR signaling pathway. Other factors (bFGF, HIF-1α, NF-κB etc.)
capable of regulating angiogenesis, are also down-regulated by some natural
products. Moreover, some of the antiangiogenic natural products also significantly
inhibit vasculogenic mimicry (VM), another important vessel recruitment avenue in
cancer, by regulating the key signaling of VM formation including VE-cadherin, EphA2, and Nodal
signaling. In this mini-review, we summarized the natural products with suppressive effect on tumor
angiogenesis and VM according to their diverse molecular mechanisms, and discussed the major
direction of future research in this field.