In this review we discuss drug design strategies directed to the
development of potential anti-influenza A(H1N1) inhibitors of M2 ion
channel, neuraminidase (NA), hemagglutinin (HA) and RNA-dependent
RNA-polymerase complex (RdRp) major targets, following temporal chronology
of their findings. Besides searching for new chemotypes, eventually
active against new targets of influenza A (H1N1), the design of optimized
analogues of proven drugs is largely pursued, taking into account the emerging
insight into the mechanisms of resistance to existing antivirals. Computational
studies are also summarized, in order to highlight the structural requirements
for further chemical optimizations.
Keywords: Influenza A(H1N1) virus, drug design, M2 ion channel blockers, HA inhibitors, NA inhibitors, RNA
polymerse complex inhibitors.
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