Title:Stimuli-responsive Smart Liposomes in Cancer Targeting
VOLUME: 19 ISSUE: 3
Author(s):Ankit Jain and Sanjay K. Jain*
Affiliation:Institute of Pharmaceutical Research, GLA University, NH-2, Mathura-Delhi Road, Mathura (U.P.) - 281 406, Pharmaceutics Research Projects Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour Central University, Sagar (M.P.) - 470 003
Keywords:Stimuli-sensitive, liposomes, thermo-sensitive, pH-sensitive, ultrasound responsive, smart delivery.
Abstract:Background: Liposomes are vesicular carriers which possess aqueous core entrapped within
the lipid bilayer. These are carriers of choice because of biocompatible and biodegradable features in addition
to flexibility of surface modifications at surface and lipid compositions of lipid bilayers.
Objective: Liposomes have been reported well for cancer treatment using both passive and active targeting
approaches however tumor microenvironment is still the biggest hurdle for safe and effective
delivery of anticancer agents. To overcome this problem, stimuli-responsive smart liposomes have
emerged as promising cargoes pioneered to anomalous tumor milieu in response to pH, temperature,
and enzymes etc. as internal triggers, and magnetic field, ultrasound, and redox potential as external
guides for enhancement of drug delivery to tumors.
Conclusion: This review focuses on all such stimuli-responsive approaches using fabrication potentiality
of liposomes in combination to various ligands, linkers, and PEGylation etc. Scientists engaged
in cancer targeting approaches can get benefited greatly with this knowledgeable assemblage of advances
in liposomal nanovectors.
