Cationic gene vectors increased attractive for gene therapy. However, unstable systemic circulation
due to the interaction of gene delivery system with blood cells limited the further application.
Therefore, pH sensitive shielding systems were exploited, by which, the positive surface charge density
of polyplexes was reduced, circulation time was improved and pH-triggered targeting delivery was
promised. This mini review mainly focuses on the development of solid tumors pH environment activated
shielding systems for cationic gene vectors. This shielding strategy shows great potential for enhancing efficient
gene transporting and achieving better therapeutic effects in acidic tumor treatment.
Keywords: Cancer therapy, gene delivery, acidity responsive, shielding strategy.
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