Title:Biodegradable Stimuli-Responsive Polymeric Micelles for Treatment of Malignancy
VOLUME: 17 ISSUE: 3
Author(s):Lesan Yan and Xingde Li
Affiliation:Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205, USA.
Keywords:Drug delivery, polymeric micelles, polypeptide and polyester, stimuli-responsive.
Abstract:In the past decade, drug delivery systems that can respond to the tumor microenvironment
or external stimuli have emerged as promising platforms for treating malignancies due to their improved
antitumor efficacy and reduced side effects. In particular, biodegradable polymeric micelles
have attracted increasing attention and been rapidly developed as a distinct therapeutic to overcome
limitations of conventional chemotherapeutic anticancer drugs. Because of their advantages with respect
to biocompatibility, degradability, circulation time, and tumor accumulation, considerable effort
has been dedicated to the developing and optimizing micellar systems during the past few years. This
review highlights recent advances concerning stimuli-responsive micelles made of biodegradable
polypeptide and polyester as nanocarries for drug delivery, and especially limits the content to pH sensitive, redox sensitive,
and photo-sensitive micellar systems for safe and efficient cancer chemotherapy.
