Development of resistance in cancer cells results in a high failure rate in cancer
chemotherapy in the clinic. Therefore, investigating the mechanisms by which cancer cells
acquire the capability to avoid cell death upon exposure to antineoplastic agents is of great
significance in cancer research. In this review article, we will provide an overview of the
mechanisms and molecular machinery of drug resistance in cancer cells which include but may
not be limited to altered membrane transport and drug metabolizing enzymes, genetic response,
enhanced DNA repair and alternation in the target molecules. A special focus will be on
describing the strategies and the rationale for exploitation of peroxisome proliferator-activated
receptors for overcoming the observed resistance in cancer cells.
Keywords: Cancer, chemotherapy, drug resistance, PPARs, P-glycoprotein, thiazolidinedione.
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