Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Complications after Surgery for Malignant Pleural Mesothelioma

Pp. 479-490 (12)

Zeynep Bilgi and Hasan F. Batirel


Malignant pleural mesothelioma prognosis is still dire. Since results are not optimal via single modality protocols, combined treatments have been proposed with more encouraging results. However, the likelihood of severe complications should be taken into the account. In this chapter, we will discuss complications due to the surgical treatment. In particular, cardiovascular complications are frequently encountered after mesothelioma surgery. Atrial fibrillation may occur in more than 50% of patients after extrapleural pneumonectomy. Myocardial infarction and serious ventricular arrhythmias are seen more rarely. Respiratory complications may include prolonged air-leak, ARDS and pneumonia. Meticulous surgical technique, proper anesthetic management with preoperative fluid restriction, and early mobilization are of paramount importance to decrease postoperative morbidity.


Complications, extrapleural pneumonectomy, postoperative morbidity, Thoracic Surgery.


Department of Thoracic Surgery, Faculty of Medicine, Marmara University, Istanbul, Turkey.