Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Results after Intraoperative Therapy in Malignant Pleural Mesothelioma

Pp. 469-478 (10)

Shamus R. Carr and Joseph S. Friedberg


Malignant pleural mesothelioma (MPM) is a virulent disease that is essentially incurable. Although surgery cannot currently be considered standard of care, there is general agreement that a certain subset of patients appear to benefit from surgery-based multimodal treatments beyond what would be expected with the current standard of care, pemetrexed-based chemotherapy alone. Exactly who those patients are remains to be defined. One intuitively appealing aspect of surgery-based therapies is that they allow for the employment of an intraoperative adjuvant therapy. There are multiple intraoperative adjuvant therapies, each with their own advantages and disadvantages. This chapter is a review of these treatments.


Intraoperative therapy, intrapleural chemotherapy, outcomes, photodynamic therapy.


University of Maryland School of Medicine, Division of Thoracic Surgery, 29 Greene St, Suite 504, 21201 Baltimore, MD, United States.