Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Surgical Treatment after Chemotherapy in Malignant Pleural Mesothelioma

Pp. 453-467 (15)

Isabelle Opitz and Walter Weder


Management of malignant pleural mesothelioma is still a clinical challenge. Currently, the best survival figures are described after multimodality regimen including macroscopic complete resection achieved by either extrapleural pneumonectomy or extended pleurectomy/decortication in patients selected for tumor biology, stage, and risk factors. One particular approach is to perform neoadjuvant chemotherapy followed by macroscopic complete resection, which will be discussed in the following chapter.


Extrapleural pneumonectomy, neoadjuvant chemotherapy, pleurectomy/decortication, thoracic surgery.


Division of Thoracic Surgery, Zurich University Hospital, Zurich, Switzerland.