Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Value of Extrapleural Pneumonectomy in Malignant Pleural Mesothelioma

Pp. 413-427 (15)

Andrea S. Wolf and Raja H. Flores


Although there is lack of consensus regarding the “standard of care” for malignant pleural mesothelioma, surgery-based multimodality therapy has demonstrated long-term survivors in multiple retrospective and prospective trials. The authors advocate radical or extended pleurectomy/decortication when possible, but for patients with adequate cardiopulmonary function in whom disease is resectable only by extrapleural pneumonectomy, this operation now has a long track record of safety and serves a critical role in the treatment of this aggressive disease.


Chemotherapy, Extrapleural pneumonectomy, thoracic surgery.


Department of Thoracic Surgery, Mount Sinai Hospital, 1176 5th Ave, 10029, New York, NY, USA.