Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Prognostic Factors in Malignant Pleural Mesothelioma

Pp. 257-283 (27)

Tommaso Claudio Mineo and Vincenzo Ambrogi


Despite recent diagnostic and therapeutic advances the prognosis of malignant pleural mesothelioma remains extremely poor. We reviewed the role of some classic (i.e. age, gender, histology, staging) and novel clinical (i.e. occult residual disease, quality of life and fluorodeoxyglucose uptake at positron emission tomography) prognosticators. Many biological and genetic machineries have been lately related with the etiology and the natural history of mesothelioma. These new factors might have a significant function in predicting the prognosis of the disease and in the next future they could reveal an important role for targeted therapies.


Genetics, prognostic factors, staging, thoracic surgery.


Division of Thoracic Surgery, Tor Vergata University Policlinic, viale Oxford 81, 00133 Rome, Italy.