Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Serum Biomarkers in Malignant Pleural Mesothelioma

Pp. 247-256 (10)

Ian M. Dick and Jenette Creaney


The interest in identifying circulating soluble biomarkers for malignant pleural mesothelioma is quite high. The studies aim at identifying a tool that could enable early detection of the disease before symptoms develop. Blood-based fibulin-3 and osteopontin studies are currently ongoing. Serum concentrations of YKL-40 had a moderate ability to discriminate between mesothelioma and other clinically relevant controls. Despite a large number of biomarkers being reported for mesothelioma in the literature, mesothelin remains the single-best blood-based biomarker for the cancer and is considered to be the ‘gold standard’.


Biomarkers, fibulin-3, mesothelin, oseopontin, YKL-40.


School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA, 6009, Australia.