Malignant Pleural Mesothelioma: Present Status and Future Directions

Malignant pleural mesothelioma is a life-threatening neoplasm of the mesothelium, the layer of tissue that covers many organs in the human body. The incidence of this type of neoplasm is gradually ...
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Anatomic Pathology of Malignant Pleural Mesothelioma

Pp. 205-212 (8)

Alfredo D’Avino and Alfonso Baldi


Mesothelioma is a rare tumor that derives from the mesothelial cells lining of body cavities. About 90-95% of mesotheliomas originate in the pleura and 5-10% in the peritoneal space. Other sites, such as pericardium and tunica vaginalis are very rare. Generally, mesotheliomas disseminate locally and tend to coat the organs in the different body cavities. The aim of this chapter is to describe the histological, histochemical, and immunohistochemical features of pleural mesotheliomas.


Calretinin, CEA, histochemistry, immunohistochemistry.


Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Naples II, Caserta, Italy.