Natural History of Malignant Pleural Mesothelioma
Pp. 25-31 (7)
Anish Thomas and Raffit Hassan
Malignant pleural mesothelioma (MPM) is an aggressive tumor of the pleural
surfaces which is most closely linked to asbestos exposure. The prognosis of MPM is
poor; morbidity and mortality results primarily by local extension or invasion of
adjacent structures and less commonly by distant metastasis. Death typically results
from extensive local involvement from primary lesions due to respiratory failure or
infection. Involvement of the heart or of the abdominal viscera may also contribute to
mortality. The best-known and commonly used clinical prognostic scoring systems for
MPM are based on work performed by European Organization for Research and
Treatment of Cancer and Cancer and Leukemia Group B which incorporate a
combination of biologic and clinical factors. This chapter will provide an overview of
the presenting symptoms and signs, prognostic factors and outcomes of MPM.
Malignant pleural mesothelioma, prognostic factors, thoracic surgery.
Thoracic and GI Oncology, National Cancer Institute, Bethesda, MD, United States.