An Efficient Four-Step Approach Toward Fused Triazino[1,6-a] Quinazolines

Author(s): Mohammad Hosein Sayahi, Shirin Baghersaei, Fereshteh Goli, Setareh Moghimi, Mohammad Mahdavi, Loghman Firoozpour, Abbas Shafiee, Alireza Foroumadi

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 19 , Issue 3 , 2016

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Herein, we describe a simple, four-step process for the preparation of 1,2,3-triazino[1,6- a]quinazolin-13-ones. This method involves ring-opening, quinazoline-forming condensation, reduction, diazotization accompanied by rapid intramolecular cyclization in the last step afforded the desired products with structurally complex heterocyclic core in excellent to high yields.

Keywords: N-N bond forming, Heterocyclization, Triazine, Quinazoline, Diazonium, Isatoic anhydride.

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Article Details

Year: 2016
Published on: 21 March, 2016
Page: [189 - 192]
Pages: 4
DOI: 10.2174/1386207319666160202120802
Price: $65

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