Asymmetric Synthesis of Trifluoromethylated Amines and Their Derivatives

Author(s): Gui-Lin Cheng, Hui Wang, Xian-Fu Lin, Qi Wu

Journal Name: Current Organic Synthesis

Volume 13 , Issue 4 , 2016


Become EABM
Become Reviewer
Call for Editor

Graphical Abstract:


Abstract:

Trifluoromethylated amines, especially optically active ones, are very important synthetic building blocks in the design of bioactive products. Over the past decades, the development of highly efficient methods for asymmetric synthesis of Trifluoromethylated amines and their derivatives has attracted a continuing interest. A brief overview will give an insight into the asymmetric synthesis of trifluoromethylated amines and their derivatives from trifluoromethyl imines, nucleophilic trifluoromethylation tamed, fluorine-containing allylic esters, and by enzymatic catalysis.

Keywords: Trifluoromethylated amines, asymmetric synthesis, nucleophilic addition, hydrogenation.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 13
ISSUE: 4
Year: 2016
Published on: 09 August, 2016
Page: [514 - 543]
Pages: 30
DOI: 10.2174/1570179413999160201151542
Price: $65

Article Metrics

PDF: 39
HTML: 1
EPUB: 1
PRC: 1