Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel

Author(s): Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao, Hui Zhang

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 16 , Issue 7 , 2016

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Abstract:

Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.

Keywords: Larotaxel, taxanes, synthesis, MCF-7, cytotoxicity, breast cancer.

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Article Details

VOLUME: 16
ISSUE: 7
Year: 2016
Page: [875 - 880]
Pages: 6
DOI: 10.2174/1871520616666160201151344
Price: $65

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