Abstract
Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.
Keywords: Cancer therapy, differentiation, mesenchymal stem cells, neoplastic transformation, telomere.
Current Stem Cell Research & Therapy
Title:Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy
Volume: 11 Issue: 4
Author(s): Nedime Serakinci, Rasime Kalkan and Pinar Tulay
Affiliation:
Keywords: Cancer therapy, differentiation, mesenchymal stem cells, neoplastic transformation, telomere.
Abstract: Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.
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Serakinci Nedime, Kalkan Rasime and Tulay Pinar, Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy, Current Stem Cell Research & Therapy 2016; 11 (4) . https://dx.doi.org/10.2174/1574888X11666160201115733
DOI https://dx.doi.org/10.2174/1574888X11666160201115733 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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