Background: Advances in preparatory and analytical technology have
greatly contributed to the maturing of metabolomics research over the past decade.
Despite this, specific limitations in sample preparation and analysis remain unresolved
within the field. More importantly, post-metabolomic application or commercialization
of discovered biomarkers is also scarce because of the lack of simplified analytical
techniques to measure these markers in the clinic or industry.
Focus: Nanotechnology can address many of these limitations and provide innovative
solutions for metabolomics sample preparation and analysis through compound entrapment
technology and nanoparticle-assisted ionization. Moreover, the creative development
of biosensors can advance the application and/or commercialization of
discovered biomarkers. This innovative use of nanotechnology in metabolomics research and biomarker
application is the focus of this paper.
Prospect: The use of existing nanotechnology in analytics is reviewed and inspirational new concepts to
improve metabolomics research are discussed as a means to encourage researchers of both fields to collaborate