Title:Therapeutic microRNA Delivery Strategies with Special Emphasis on Cancer Therapy and Tumorigenesis: Current Trends and Future Challenges
VOLUME: 17 ISSUE: 5
Author(s):Chiranjib Chakraborty, Zhi-Hong Wen, Govindasamy Agoramoorthy and Chan-Shing Lin
Affiliation:Department of Marine Biotechnology and Resources, College of Marine Sciences, and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yatsen University, Kaohisung, Taiwan., Department of Marine Biotechnology and Resources, College of Marine Sciences, and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yatsen University, Kaohisung, Taiwan.
Keywords:Biopharmaceutical industry, cancer therapy, miRNA delivery, therapeutic microRNA, tumorigenesis.
Abstract:Background: Over the decade, miRNAs are the most important molecules for the biopharmaceutical industry
due to their relation with several human diseases. Presently, the phase-II clinical trial has been initiated for
the first miRNA-based therapeutics (“Miravirsen”) to treat HCV infection. It has been expected that many more
miRNA-based therapeutics will enter the clinical trials. Therefore, it is important to develop different kinds of
novel delivery systems with better efficacy and more efficiency, but fewer side effects.
Methods: We have undertaken a structured search of bibliographic databases for peer-reviewed research literature
to solve our review question. Literature survey was performed widely to write this review article.
Results: In this review, we have discussed the various types of miRNA delivery systems such as viral vectors, lipid-based systems, nanocarriers,
and LNA-customized DNA delivery without any delivery-mediated agent. Current status, technical support, and the future challenges
for miRNA-based delivery are also discussed.
Conclusion: Recent development and understanding of miRNA had shown the therapeutic potentiality of miRNA.
