This review focuses on the clinical and biological features of the bioresorbable scaffolds in
interventional cardiology highlighting scientific achievements and challenges of the transient scaffolding
with Absorb BVS. Special attention is granted to the vascular biology pathways which, involved
in the resorption of scaffold, artery remodeling and mechanisms of Glagovian atheroregression setting
the stage for subsequent clinical applications. Twenty five years ago Glagov described the phenomenon
of limited external elastic membrane enlargement in response to an increase in plaque burden. We
believe this threshold becomes the target for development of strategies that reverse atherosclerosis,
and particularly transient scaffolding has a potential to be a tool to ultimately conquer atherosclerosis.
Keywords: Artery remodeling, atheroregression, bioresorption, bioresorbable scaffold, glagov phenomenon, stenting.
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