Abstract
Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RPHPLC method following 5,15, 30, 60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.
Keywords: Selegiline, pharmacokinetics, rabbit, blood-brain penetration, blood-testis penetration, iris, cornea, retina.
Letters in Drug Design & Discovery
Title:Pharmacokinetics of Selegiline in a Rabbit Model
Volume: 13 Issue: 8
Author(s): Huba Kalász, Kornélia Tekes, Zita Pöstényi, Eszter Vizvári, Péter Sótonyi, Dóra Szabó and Edit Tóth-Molnár
Affiliation:
Keywords: Selegiline, pharmacokinetics, rabbit, blood-brain penetration, blood-testis penetration, iris, cornea, retina.
Abstract: Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RPHPLC method following 5,15, 30, 60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.
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Kalász Huba, Tekes Kornélia, Pöstényi Zita, Vizvári Eszter, Sótonyi Péter, Szabó Dóra and Tóth-Molnár Edit, Pharmacokinetics of Selegiline in a Rabbit Model, Letters in Drug Design & Discovery 2016; 13 (8) . https://dx.doi.org/10.2174/1570180813666160125224604
DOI https://dx.doi.org/10.2174/1570180813666160125224604 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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