A series of novel biphenyl derivatives with -aminophosphonate moiety was designed and
successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The structures of
the target compounds were confirmed by 1H NMR, 13C NMR, 31P NMR, IR and H MRS. The antiviral
activity against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) indicated that most
of the target compounds exhibited certain anti-TMV and good anti-CMV activities, respectively, in which compound 4d
displayed higher anti-TMV activity and compound 4s exhibited higher anti-CMV activity than the commercial agent
Keywords: Biphenyl derivatives, α-aminophosphonate, antiviral activity, synthesis.
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