Novel Biphenyl Derivatives with α-Aminophosphonate Moiety: Design, Synthesis and Antivirus Activity

Author(s): Guo-Ping Zhang, Min Liu.

Journal Name: Letters in Drug Design & Discovery

Volume 13 , Issue 7 , 2016

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Abstract:

A series of novel biphenyl derivatives with -aminophosphonate moiety was designed and successively synthesized through Suzuki-Miyaura and Kabachnik-Fields reaction. The structures of the target compounds were confirmed by 1H NMR, 13C NMR, 31P NMR, IR and H MRS. The antiviral activity against tobacco mosaic virus (TMV) and cucumber mosaic virus (CMV) indicated that most of the target compounds exhibited certain anti-TMV and good anti-CMV activities, respectively, in which compound 4d displayed higher anti-TMV activity and compound 4s exhibited higher anti-CMV activity than the commercial agent Ningnanmycin.

Keywords: Biphenyl derivatives, α-aminophosphonate, antiviral activity, synthesis.

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Article Details

VOLUME: 13
ISSUE: 7
Year: 2016
Page: [706 - 714]
Pages: 9
DOI: 10.2174/1570180813666160125222813
Price: $65

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