Nano-Carrier Systems: An Overview of Poly-Art and Peptide Conjugates

Author(s): Permender Rathee, Anjoo Kamboj, Shabir Sidhu

Journal Name: Current Nanomedicine
(Formerly Recent Patents on Nanomedicine)

Volume 6 , Issue 1 , 2016

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Objective: The aim is to describe the role and function of polymer or peptide mediated drug delivery system considerations in Nano-formulations.

Background: The Polymers are the basic frameworks of any formulation, more importantly in case of Sustained/controlled release or Nano-particulate forms. The most commonly used polymers composed of PLA (Poly Lactic Acids).

Methods: A systematic search of the published literature was performed by using MEDLINE, EMBASE, the Cochrane Library and Patent Databases.

Results: More than 20 patents and 60 research and review papers were selected and studied in which PLA’s had been used as a formulating agent. The data from literature was transformed in tabular forms for better comparison and understanding of role and function of polymer or peptide mediated drug delivery system considerations.

Conclusion: These transformations usually aid to achieve the desired in-vivo biological activity by protecting the molecule’s first pass metabolism and overcoming toxicity. Moreover, these peptide polymer conjugates have numbers of biomedical remedy applications in the various disorders. These poly-peptide conjugates have been approved by the World Health Organization (WHO) and the Food and Drug Administration (FDA) as materials that can be used in medicine/pharmaceutical delivery vehicles.

Keywords: Applications, bio-medical, peptides, poly-(meric)-acids, polymers, therapeutic.

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Article Details

Year: 2016
Published on: 03 March, 2016
Page: [50 - 62]
Pages: 13
DOI: 10.2174/1877912306999160122160351

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