The triazoles 3a-d underwent condensation reactions with 4-(piperidin-1-yl)-benzaldehyde
to afford the chalcones 5a-d. Chalcone derivatives 5a-d were reacted with 2,3-diaminomaleonitrile,
thiourea and hydrazine hydrate to afford the novel diazepine-dicarbonitrile derivatives 7a-d, the
pyrimidine-2-thiol derivatives 9a-d and hydrazino-pyrimidines 10a-d respectively. Structures of the prepared compounds
were elucidated by physical and spectral data like FT-IR, 1H NMR, 13C NMR, and mass spectroscopy. Some of the
synthesized compounds were screened for their anticonvulsant activity and SAR.
Keywords: Anticonvulsant activity, chalcones, diazepines, hydrazino-pyrimidines, pyrimidine-thioles, 1, 2, 3-triazoles,
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