Efficient control of the infectious diseases in the era of the emerging bacterial resistance demands consistent
development of new antibiotic agents with novel modes of action. With some notable exceptions, the majority
of the currently used antibiotics are natural product-derived compounds which were elaborated upon lead
structures discovered by screening of various isolates. In this review, we summarized some selected examples of
recent advances in the area of natural product based antibiotic development with particular emphasis on the synthetic
and SAR-elucidation aspects.
Keywords: Natural products, antibiotics, total synthesis, structure-activity relationship studies.
Rights & PermissionsPrintExport