Abstract
Efficient control of the infectious diseases in the era of the emerging bacterial resistance demands consistent development of new antibiotic agents with novel modes of action. With some notable exceptions, the majority of the currently used antibiotics are natural product-derived compounds which were elaborated upon lead structures discovered by screening of various isolates. In this review, we summarized some selected examples of recent advances in the area of natural product based antibiotic development with particular emphasis on the synthetic and SAR-elucidation aspects.
Keywords: Natural products, antibiotics, total synthesis, structure-activity relationship studies.
Current Pharmaceutical Design
Title:Natural Product-Based Antibiotics: Synthesis and SAR-Studies.
Volume: 22 Issue: 12
Author(s): Evgeny V. Prusov
Affiliation:
Keywords: Natural products, antibiotics, total synthesis, structure-activity relationship studies.
Abstract: Efficient control of the infectious diseases in the era of the emerging bacterial resistance demands consistent development of new antibiotic agents with novel modes of action. With some notable exceptions, the majority of the currently used antibiotics are natural product-derived compounds which were elaborated upon lead structures discovered by screening of various isolates. In this review, we summarized some selected examples of recent advances in the area of natural product based antibiotic development with particular emphasis on the synthetic and SAR-elucidation aspects.
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Cite this article as:
Prusov V. Evgeny, Natural Product-Based Antibiotics: Synthesis and SAR-Studies., Current Pharmaceutical Design 2016; 22 (12) . https://dx.doi.org/10.2174/1381612822666160115130633
DOI https://dx.doi.org/10.2174/1381612822666160115130633 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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