Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis
(Mtb), which primarily affects the respiratory tract. Combinations of drugs are used for therapeutic
synergism and to prevent the emergence of drug resistant strains, but even first- or secondchoice
drugs present some disadvantages, such as significant side effects and the need for long
duration of treatments. Thus, new strategies for TB control and treatment are highly demanded. In this context, protein tyrosine phosphatases
(PtpA and PtpB) are secreted by Mtb within the host macrophage and they have been shown to contribute to Mtb pathogenicity. The
understanding of the role of these PTPs has led to interesting anti-TB drugs discovery. Here, we review the current knowledge on these
two proteins as targets for novel anti-TB therapies, with particular emphasis on their mechanism of action and current advancements in
developing small molecule inhibitors from natural sources.
Keywords: Tuberculosis, Mycobacterium tuberculosis, tyrosine phosphatases, PtpA, PtpB.
Rights & PermissionsPrintExport